Endometrial Receptivity Analysis

Endometrial Receptivity Analysis (ERA) is an advanced diagnostic test used in fertility treatments to determine the optimal time for embryo transfer. The test involves performing an endometrial biopsy to collect a small sample of the lining of the uterus (endometrium), followed by gene expression analysis to assess the receptivity of the endometrial tissue. This helps identify the precise “window of implantation,” which is the period when the endometrium is most receptive to embryo implantation.

How ERA Testing Works

• Endometrial Biopsy:

  • A small tissue sample is taken from the endometrium during a specific phase of the woman’s menstrual cycle. This process is minimally invasive and typically performed in the doctor’s office.

• Gene Expression Analysis:

  • The collected tissue is then analyzed in a laboratory, where over 200 genes related to endometrial receptivity are examined. This provides insights into whether the endometrium is ready for implantation at the time the biopsy was performed.

• Personalized Embryo Transfer Timing:

  • The ERA test helps pinpoint the exact timing for an embryo transfer based on the woman’s unique biological clock. This “personalized window of implantation” ensures that the embryo is transferred at the most receptive moment, improving the chances of successful implantation and pregnancy.
    
    

Benefits of ERA Testing

• Improved Embryo Implantation Rates:

  • By synchronizing the embryo transfer with the individualized window of implantation, ERA helps increase the chances of successful implantation, particularly in women who have experienced recurrent implantation failure in IVF treatments.

• Personalized Treatment:

  • Every woman’s reproductive system operates differently, and ERA provides a customized approach by offering personalized data on the optimal time for embryo transfer.

• Reduces the Risk of Failed IVF Cycles:

  • For women who have undergone multiple failed IVF attempts, ERA testing offers a way to better align the timing of embryo transfer with the endometrial receptivity, potentially reducing the need for repeated cycles.