Complex IVF Treatment for Infertile Couples with Multiple failures of Pregnancies

Infertility is a disorder in which people are unable to have children after one year of regular intercourse. The incidence of infertility is increasing.  Worldwide it is estimated 10 percent of couples are infertile. Infertility can be an individual or a couple’s problem.

In this article, we will discuss complex IVF treatment for infertile couples with multiple failures of pregnancies. In vitro fertilization (IVF) is a process that combines egg and sperm in a laboratory dish and then to transfer the embryo into the woman’s body. IVF treatment is used for various causes of infertility, most common being tubal block, less sperm count, low ovarian reserve, endometriosis, unexplained infertility, and multiple IUI failures

Causes of implantation failure in IVF

The treatment of infertility depends on the cause of infertility, the age and health condition of partners, their preferences and other important factors. If you are trying to conceive via In Vitro Fertilization, it’s important to understand that not every embryo will successfully implant.


As women age, they are more likely to have the egg cells they produce become genetically damaged. This, in turn, has a negative effect on the ability of the embryo to implant and grow.The most common reason for implantation failure in IVFin advanced  maternal age is due to an egg having an abnormal genetic makeup leading to weak or unhealthy embryos

Uterine factors

The following are some uterine reasons behind implantation failure in IVF:

  • Fibroids/Big Polyp/Septum/Adhesions/ TB Uterus /Asherman’s syndrome(lot of scar tissue in uterine cavity)

Other reasons of Implantation failure

  • Immune system issues
  • Lifestyle factors
  • Severe male factor

Success After Repeated Implantation Failure

This is a particularly encouraging success story of a woman, who had been trying unsuccessfully for over three years after unsuccessful attempts with IVF, donor egg, and embryo donation to have a baby. She had been through three cycles of IVF-ICSI at a well-known clinic and failed to produce any viable pregnancy. After her third failed attempt, she decided to consult with her new doctor in January 2020.

The treatment was started in March 2020 and in December 2020 she conceived and delivered a healthy baby boy after nearly four years of seeking help. The doctor guided her through the entire course of treatment and delivered a healthy baby boy

In this case, the patient did go through a thorough diagnostic evaluation and undergo a few minor surgical procedures to remove fibroids from the uterus, which is known to reduce fertility significantly in women. The patient also underwent an ERA procedure, which increase the chances of implantation.

Infertility Treatment for Male and Female

Male Fertility Treatment:

  • Surgery
  • Antibiotics
  • Medications and counseling
  • Hormone treatments

Female Fertility Treatment:

  • Fertility drugs
  • Surgery
  • Endoscopy(Hysteroscopy and Laparoscopy)
  • ERA test
  • Embryo
  • Blastocyst Culture
  • Assisted Hatching

Pre-Implantation Genetic Screening

For both males and females, infertility can also be treated with assisted reproductive technology (ART). The following are different types of ART:

  1. IUI (intrauterine insemination)
  2. IVF (in vitro fertilization)
  3. ICSI(intracytoplasmic sperm injection)


With the aid of medical technologies like IVF, there is new hope for infertile couples to conceive even after multiple failures of pregnancy. We wish we were able to clear your doubts about complex IVF treatment for infertile couples with multiple failures of pregnancies. We wish you good luck and hope for the best.